John Clayton
John Clayton may refer to:
- John Clayton (divine)
- John Clayton (painter)
- John M. Clayton (1796 – 1856), U.S. Senator from Delaware and U.S. Secretary of State
- John M. Clayton (Arkansas) (1840 – 1889), Arkansas carpetbagger, assassinated 1889
- John Clayton (sportscaster), writer and reporter for ESPN and SportsCenter
- John Clayton (bassist), American jazz bassist
- John Clayton (botanist) (1694 – 1773), Colonial Virginia
- John Clayton (cricketer) (1857 — 1938), English cricketer
- John Clayton (footballer), Scottish footballer
- John Clayton (town clerk) (1792 - 1890), antiquarian and town clerk of Newcastle upon Tyne, England
- John Clayton, Lord Greystoke, birthname of the fictional character Tarzan
- John Bell Clayton and Martha Clayton (c1907-1955) & (1915-1961), American writers
- John Clayton (actor) (1940 – 2003), Australian actor
- John Clayton Adams (1840 – 1906), English landscape artist
- John Clayton Allen (1860 - 1939), American politician
- Jack Clayton (1921 – 1995), British film director